The new guidelines are expected to significantly affect clinical practice. Among the highlights:

• Cardiac radionuclide imaging is considered appropriate in patients with an intermediate or high likelihood of CAD, and in patients with a low likelihood if they were unable to exercise or had an uninterpretable electrocardiogram (ECG).

• Thrombolysis in myocardial infarction (TIMI) scores were incorporated into the indications describing acute chest pain syndromes to provide a more comprehensive risk assessment model consistent with literature, using a score of 2 as a threshold for high/low risk.

• For patients with suspected acute coronary syndrome, RNI was considered appropriate irrespective of the TIMI score or whether or not their troponin levels were elevated.

• In asymptomatic patients, RNI is appropriate only in patients at high risk of coronary heart disease; in those with intermediate coronary heart disease risk with an uninterpretable ECG, RNI is considered uncertain.

• The presence of unexplained troponin elevation, newly diagnosed heart failure, and ventricular tachycardia are appropriate indications for RNI, but RNI is of uncertain appropriateness in the setting of atrial fibrillation.

• RNI is inappropriate if prior test results were known, except when performed more than two years later and only if an abnormal study was previously present or if the patient is at intermediate or greater risk of coronary heart disease.

• Overall, RNI is considered inappropriate for preoperative risk assessment, except in the setting of intermediate risk or vascular surgery when at least one risk factor is present and the patient has a limited functional capacity.

• Within three months following an acute coronary syndrome, RNI is inappropriate except in patients without prior coronary angiography.

• After considerable discussion, the researchers decided to remove prerevascularization symptomatology as a discrimination point within the SPECT myocardial perfusion indication due to a lack of evidence that this qualification was relevant.

• The routine use of first-pass radionuclide angiography imaging is inappropriate, but appropriateness is considered uncertain when used selectively -- for example, in patients with suspected multivessel coronary disease.